Dentate gyrus neurons that are born at the peak of development, but not before or after, die in adulthood.

Tina CiricShaina P CahillJason Scott Snyder

Published in: Brain and behavior (2019)

Delayed death of P6-born neurons suggests these cells may play a unique role in hippocampal plasticity adulthood, for example, by contributing to the turnover of hippocampal memory. Their loss may also play a role in disorders that are characterized by hippocampal atrophy.

Keyphrases

spinal cord
cerebral ischemia
induced apoptosis
depressive symptoms
gestational age
low birth weight
temporal lobe epilepsy
cell cycle arrest
working memory
spinal cord injury
cell death
cell proliferation
brain injury
postmenopausal women
pi k akt