Vitamin C (Ascorbic acid) protects from neuropathy caused by cisplatin, through enhanced heat shock protein-70 and reduced oxidant effect.

Emel Ebru Pala Halil Gursoy Pala Sümeyye Ekmekçi Oytun Erbaş

Published in: Revista da Associacao Medica Brasileira (1992) (2022)

We demonstrated the ameliorated effects of vitamin C on cisplatin-induced neuropathy through increased heat shock protein-70, nerve growth factor levels, and reduced inflammatory and oxidant effects. The results are promising to improve the neurotoxic effects of cisplatin in cancer patients.

Keyphrases

heat shock protein
growth factor
heat shock
anti inflammatory
oxidative stress
peripheral nerve