Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice.
Rosemary M ClarkCourtney M ClarkKatherine E A LewisMarcus S DyerJyoti A ChuckowreeJoshua A HoyleCatherine A BlizzardTracey C DicksonPublished in: Annals of clinical and translational neurology (2023)
Taken together, these findings highlight the capacity for non-invasive brain-targeted interventions in ALS and support antagonism of NPY Y1Rs as a novel strategy to improve ALS motor function.