Associations of reproductive factors and exogenous estrogens with global and domain-specific cognition in later life.
Jillian K LeeRyan D FrankLuke R ChristensonJulie A FieldsWalter A RoccaMichelle M MielkePublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
The length of a woman's reproductive window was not associated with cognition longitudinally. Greater parity was associated with greater cognitive decline longitudinally. Ever HC use was associated with less decline in global cognition and all domain-specific z-scores longitudinally (all p < 0.01). Ever MHT use was associated with greater decline in global cognition and all domain-specific z-scores except visuospatial longitudinally (all p < 0.01). The greatest cognitive decline was among women who initiated MHT more than 5 years after menopause.