Evaluation of mixtures of flavor chemicals in a 90-day nose-only exposures in sprague-dawley rats.
Michael J OldhamRahat Wadhwa DesaiJames RandazzoBrent E WallingGuy LalondeRoxana WeilPublished in: Human & experimental toxicology (2024)
Based on the absence of adverse effects, the no-observed-adverse-effect concentration for each 90-day inhalation study was the highest dose tested, 2.5 mg/L of the aerosolized high dose of the three flavor mixtures.