Global early replication disrupts gene expression and chromatin conformation in a single cell cycle.

Miguel Monteiro Santos Mark C Johnson Lukáš Fiedler Philip Zegerman

Published in: Genome biology (2022)

Together, these data provide new insight into the role of the temporal control of origin firing during S-phase for coordinating replication, gene expression, and chromatin establishment as occurs in the early embryo.

Keyphrases

gene expression
cell cycle
dna methylation
cell proliferation
dna damage
genome wide
transcription factor
electronic health record
big data
molecular dynamics simulations
machine learning
artificial intelligence