Camouflaged Nanosilver with Excitation Wavelength Dependent High Quantum Yield for Targeted Theranostic.
Agnishwar GirigoswamiWafic YassinePalani SharmiladeviViswanathan HaribabuKoyeli GirigoswamiPublished in: Scientific reports (2018)
The present study shows the thorough investigations on optical properties and hydrodynamic diameters of glutathione (GSH) stabilized nanosilver clusters (AgNC) at different stages of synthesis and engineering for the optimized absolute quantum yield to generate fluorescent images of Dalton Lymphoma Ascites (DLA) tumour bearing mice. The initial increment of quantum yield was wavelength dependent and finally it became 0.509 which was due to the camouflaging or entrapment of AgNC in macrophages membranes. The potentiality of macrophages membrane camouflaged silver nanoclusters (AgM) was reflected in the cell viability assay and confocal based live dead cell assay where the AgM has better cell killing effect compared to AgNC with reduced dosage and in vivo mice imaging generated the clear visualization at the tumour sites. Therefore, from the present study, it can be considered that the camouflaged nanosilver can be used for targeted theranostic applications.
Keyphrases
- molecular dynamics
- energy transfer
- single cell
- photodynamic therapy
- high throughput
- cell therapy
- high resolution
- gold nanoparticles
- cancer therapy
- fluorescence imaging
- type diabetes
- stem cells
- quantum dots
- fluorescent probe
- skeletal muscle
- high fat diet induced
- mass spectrometry
- drug delivery
- living cells
- convolutional neural network
- sensitive detection
- machine learning
- bone marrow
- raman spectroscopy
- adipose tissue