Molecular and Cellular Mechanisms of Cytotoxic Activity of Vanadium Compounds against Cancer Cells.
Szymon KowalskiDariusz WyrzykowskiIwona Inkielewicz-StepniakPublished in: Molecules (Basel, Switzerland) (2020)
Discovering that metals are essential for the structure and function of biomolecules has given a completely new perspective on the role of metal ions in living organisms. Nowadays, the design and synthesis of new metal-based compounds, as well as metal ion binding components, for the treatment of human diseases is one of the main aims of bioinorganic chemistry. One of the areas in vanadium-based compound research is their potential anticancer activity. In this review, we summarize recent molecular and cellular mechanisms in the cytotoxic activity of many different synthetic vanadium complexes as well as inorganic salts. Such mechanisms shall include DNA binding, oxidative stress, cell cycle regulation and programed cell death. We focus mainly on cellular studies involving many type of cancer cell lines trying to highlight some new significant advances.
Keyphrases
- cell cycle
- dna binding
- cell death
- oxidative stress
- cell proliferation
- endothelial cells
- transcription factor
- human health
- papillary thyroid
- squamous cell carcinoma
- risk assessment
- ionic liquid
- quantum dots
- ischemia reperfusion injury
- health risk
- squamous cell
- combination therapy
- heavy metals
- induced pluripotent stem cells
- health risk assessment
- lymph node metastasis
- diabetic rats
- heat shock protein
- heat shock