Photobiomodulation at 660 nm Stimulates Fibroblast Differentiation.

Dimakatso R MokoenaNicolette Nadene Houreld Sathish Sundar Dhilip Kumar Abrahamse Heidi

Published in: Lasers in surgery and medicine (2019)

PBM at 660 nm with 5 J/cm2 was successful in stimulating the differentiation of fibroblasts into myofibroblasts in diabetic wounded cells, which was independent of the TGF-β1/Smad pathway. Fibroblast transition into myofibroblasts is vital to wound healing, failure of which results in impaired healing; PBM is able to foster such a transition. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

Keyphrases

wound healing
transforming growth factor
induced apoptosis
photodynamic therapy
cell cycle arrest
epithelial mesenchymal transition
endoplasmic reticulum stress
extracellular matrix
cell death