Magnesium sulfate differentially modulates fetal membrane inflammation in a time-dependent manner.
Sarah N CrossRachel A NelsonJulie A PotterErrol R NorwitzVikki M AbrahamsPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
Magnesium sulfate differentially modulates LPS-induced FM inflammation in a time-dependent manner, in part through its modulation of caspase-1 activity. Thus, the timing of MgSO4 administration may be critical in optimizing its anti-inflammatory effects in the clinical setting. MgSO4 might also be useful at preventing FM inflammation triggered by a polymicrobial viral-bacterial infection.