Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice.

Christelle KnudsenAudrey M NeyrinckQuentin LeyrollePamela BaldinSophie LeclercqJulie RodriguezMartin BeaumontPatrice D CaniLaure B BindelsNicolas LanthierNathalie M Delzenne

Published in: The Journal of nutrition (2022)

Our results support the efficacy of indole to reduce hepatic damage and associated inflammatory response and macrophage activation in ob/ob mice. These modifications appear to be attributable to direct effects of indole on the liver, rather than through effects on the adipose tissue or intestinal barrier.

Keyphrases

adipose tissue
inflammatory response
insulin resistance
microbial community
lipopolysaccharide induced
oxidative stress
high fat diet
high fat diet induced
type diabetes
toll like receptor
metabolic syndrome