Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet.

Masatoki YoshidaKazufumi NakamuraToru MiyoshiMasashi YoshidaMegumi KondoKaoru AkazawaTomonari KimuraHiroaki OhtsukaYuko OhnoDaiji MiuraHiroshi Ito

Published in: Cardiovascular diabetology (2020)

Combination therapy with pitavastatin and pemafibrate improved lipid profiles and endothelial dysfunction in hypertension and insulin resistance model rats. Pemafibrate as an add-on strategy to statins may be useful for preventing atherosclerosis progression.

Keyphrases

combination therapy
high fat diet
insulin resistance
adipose tissue
cardiovascular disease
blood pressure
metabolic syndrome
skeletal muscle
type diabetes
polycystic ovary syndrome
high fat diet induced
glycemic control