Evidence supporting safe diagnosis of coeliac disease in children with antitissue transglutaminase titre ≥5 times upper limit of normal.
Jonathan Wayland GrahamDaniyal Isam RajaBhupinder Kaur SandhuSrinivasa R RaoChristine H SprayAnthony Edward WiskinLakshmipriya SelvarajanEleni VolonakiPramila RamaniLina Bourhan TashtoushDharamveer BasudePublished in: Archives of disease in childhood (2022)
99.5% of children with TGA-IgA ≥5×ULN had histological confirmation of CD, suggesting that CD diagnosis can be made securely in children with TGA-IgA ≥5×ULN. If other studies confirm this finding, there is a case to be made to modify the ESPGHAN guidelines to a lower threshold of TGA-IgA for serological diagnosis of CD.
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