Dual targeting of apoptotic and signaling pathways in T-lineage acute lymphoblastic leukemia.
Caner SayginGiorgia GiordanoKathryn ShimamotoBartholomew J EisfelderAnika Thomas-TothGirish VenkataramanVijayalakshmi AnanthanarayananTiffaney L VincentAdam S DuVallAnand Ashwin PatelYi ChenFenlai TanStephen P AnthonyYu ChenYue ShenOlatoyosi OdenikeDavid Trent TeacheyBarbara L KeeJames L LaBelleWendy StockPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
LCK and ACK1 signaling pathways are critical regulators of BH3 mimetic resistance in T-ALL. Combination of BH3 mimetics with tyrosine kinase inhibitors might be effective against relapsed T-ALL.
Keyphrases
- acute lymphoblastic leukemia
- signaling pathway
- pi k akt
- allogeneic hematopoietic stem cell transplantation
- cell death
- epithelial mesenchymal transition
- induced apoptosis
- transcription factor
- acute myeloid leukemia
- single cell
- cancer therapy
- multiple myeloma
- cell proliferation
- drug delivery
- chronic myeloid leukemia