Proangiogenic Hypoxia-Mimicking Agents Attenuate Osteogenic Potential of Adipose Stem/Stromal Cells.

Ahmed G Abu-Shahba Arjen Gebraad Sippy KaurRiku O PaananenHilkka PeltoniemiRiitta Seppänen-Kaijansinkko Bettina Mannerström

Published in: Tissue engineering and regenerative medicine (2020)

PHIs significantly reduced the osteogenic differentiation of AT-MSCs and rather upregulated stemness-related genes. PHIs proangiogenic potential should be weighed against their longterm direct inhibitory effects on the osteogenic differentiation of AT-MSCs.

Keyphrases

mesenchymal stem cells
umbilical cord
stem cells
epithelial mesenchymal transition
endothelial cells
type diabetes
risk assessment
signaling pathway
skeletal muscle