A simulation tool for mechanical circulatory support device interaction with diseased states.

David J HorvathDennis W HorvathJamshid H KarimovBarry D KubanTakuma MiyamotoKiyotaka Fukamachi

Published in: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs (2020)

We have created a simulation model to investigate the interactions between a variety of mechanical circulatory support (MCS) devices and the circulatory system with various simulated patient conditions and disease states. The present simulation accommodates a family of continuous-flow MCS devices under various stages of consideration or development at our institution. This article describes the mathematical core of the in silico simulation system and shows examples of simulation output imitating various disease states and of selected in vitro and clinical data from the literature.

Keyphrases

virtual reality
extracorporeal membrane oxygenation
electronic health record
big data
molecular dynamics simulations