Syndecan-4 inhibition attenuates cartilage degeneration in temporomandibular joint osteoarthritis.

Xiaohua ChenFeng HeHongyun ZhangYuanjun MaJia YuHan QinFan WuZhuo WangYing ZhanJing ZhangLei LuMian Zhang Shibin Yu

Published in: Journal of oral rehabilitation (2024)

SDC4 inhibition significantly ameliorates condylar cartilage degeneration, which was mediated, at least partly, through P38 and ERK1/2 signalling. Inhibition of SDC4 may be of great value for the treatment of TMJOA.

Keyphrases

signaling pathway
rheumatoid arthritis
extracellular matrix
cell proliferation
knee osteoarthritis
smoking cessation
replacement therapy