Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy in totally thyroidectomized subjects: the LEVOLIO study.
Brigante GiuliaDaniele SantiGisella BoselliGianluca MargiottaRossella CorletoMaria Laura MonzaniAndrea CraparoMichela LocasoSamantha SperdutiNeena RoyCasarini LivioTommaso TrentiSimonetta TagliaviniMaria Cristina De SantisLaura RoliVincenzo RochiraManuela SimoniPublished in: European journal of endocrinology (2024)
Six months of combination therapy with twice-daily LT3 dose adapted according to TSH-level do not significantly change peripheral tissue response or quality of life, despite an increase in the fT3/fT4 ratio.