Nuclear receptor co-repressor NCOR2 and its relation to GPER with prognostic impact in ovarian cancer.

Juliane ReichenbachPatricia FraungruberDoris MayrChristina BuschmannFabian B T KrausNicole Elisabeth TopalovAnca Chelariu-RaicuThomas KolbenAlexander BurgesSven MahnerMirjana KesslerUdo JeschkeBastian CzogallaFabian Trillsch

Published in: Journal of cancer research and clinical oncology (2023)

Our results support the hypothesis that nuclear co-repressors such as NCOR2 may influence the transcription of target genes in EOC such as GPER. Understanding the role of nuclear co-repressors on signaling pathways will allow a better understanding of the factors involved in prognosis and clinical outcome of EOC patients.

Keyphrases

end stage renal disease
signaling pathway
chronic kidney disease
ejection fraction
newly diagnosed
prognostic factors
estrogen receptor
transcription factor
gene expression
cell proliferation
oxidative stress
dna methylation
binding protein