An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers.

Rhitajit Sarkar Priyanka Bolel Abhijeet KapoorElena EliseevaAndrés E Dulcey Jay S TemplinAmy Q WangXin XuNoel SouthallJoanna Klubo-Gwiedzdzinska Susanne Neumann Juan Jose Marugan Marvin Carl Gershengorn

Published in: The Journal of clinical endocrinology and metabolism (2024)

We conclude that A35 is a TSHR-selective inhibitor of TC cell proliferation and metastasis, and suggest that A35 may be a promising lead drug candidate for the treatment of differentiated TC in humans.

Keyphrases

cell proliferation
squamous cell carcinoma
small cell lung cancer
cell cycle
emergency department
drug induced
binding protein
childhood cancer