A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death.
Louise E See HoeKarin WildiNchafatso G ObonyoNicole BartnikowskiCharles McDonaldKei SatoSilver HeinsarSanne Engkilde-PedersenSara DiabMargaret R PassmoreMatthew A WellsAi-Ching BoonArlanna EsguerraDavid G PlattsLynnette JamesMahe BouquetKieran HyslopTristan ShukerCarmen AinolaSebastiano M ColomboEmily S WilsonJonathan E MillarMaximillian V MalfertheinerJanice D ReidHollier O'NeillSamantha LivingstoneGabriella AbbateNoriko SatoTing HeViktor von BahrSacha RozencwajgLiam ByrneLeticia P PimentaLachlan MarshallLawrie NairJohn-Paul TungJonathan ChanHaris HaqqaniPeter MolenaarGianluigi Li BassiJacky Y SuenDavid C McGiffinJohn F FraserPublished in: Intensive care medicine experimental (2021)
We have successfully developed an ovine HTx model following 24 h of donor BSD. After 6 h of critical care management post-HTx, there were no differences between groups, despite evident hemodynamic perturbations, systemic inflammation, and cardiac injury observed during donor BSD. This preclinical model provides a platform for critical assessment of injury development pre- and post-HTx, and novel therapeutic evaluation.