Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats.

Ryan T McCallumRachel-Karson ThériaultJoshua D ManducaIsaac S B RussellAngel M CulmerJanan Shoja DoostTami A MartinoMelissa L Perreault

Published in: Biology of sex differences (2024)

Collectively, these findings support a greater role of immune processes in males than females in a rodent model of depression. This suggests that pharmacotherapies that target Nrf2 have the potential to be an effective sex-specific treatment for depression.

Keyphrases

stress induced
depressive symptoms
sleep quality
oxidative stress
mouse model
risk assessment