Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia.

Alak MannaSonikpreet AulakhPrachi JaniSalman AhmedSharoon AkhtarMarie CoignetMichael HeckmanZahara MeghjiKirtipal BhatiaAarushi SharmaTaimur SherVictoria AlegriaFabio MalavasiEduardo N ChiniAsher Chanan-KhanSikander AilawadhiAneel Paulus

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Overall, our data demonstrate the antitumor mechanisms of daratumumab in CLL; furthermore, we show how cotargeting BTK and CD38 lead to a robust anti-CLL effect, which has clinical implications.

Keyphrases

chronic lymphocytic leukemia
tyrosine kinase
big data
machine learning
deep learning