Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice.

males had more severe fibrosis and inflammation than male Balb/c mice. In females, the HFCD-induced hepatocellular damage and the immune response are less affected by NKT cells on early steatohepatitis progression, underscoring sex-specific NKT-cell influence in MASH development.