Sequence-directed dynamic covalent assembly of base-4-encoded oligomers.
Samuel C LeguizamonM F DunnTimothy F ScottPublished in: Chemical communications (Cambridge, England) (2020)
As an information-bearing biomacromolecule, DNA is encoded in base-4, where each residue site can be occupied by any one of four nucleobases. Mimicking the information dense, sequence-selective hybridization of DNA, we demonstrate two orthogonal dynamic covalent interactions to effect the selective assembly of molecular ladders and grids from base-4-encoded oligo(peptoid)s.