Validation of a diet-induced Macaca fascicularis model of non-alcoholic steatohepatitis with dietary and pioglitazone interventions.

Raul C Camacho David C Polidori Tao ChenBin ChenHelen Han HsuBin GaoMathieu MarellaMariusz LubomirskiTraymon BeaversJavier CabreraPeggy WongAndrea R Nawrocki

Published in: Diabetes, obesity & metabolism (2023)

Both weight loss induced by DSCR and treatment with pioglitazone improve the histological features of NASH in a diet-induced cynomolgus monkey model. This model provides a translational preclinical model for testing novel NASH therapies.

Keyphrases

weight loss
type diabetes
physical activity
insulin resistance
liver fibrosis