N-methyl-D-aspartate receptor antibody production from germinal center reactions: Therapeutic implications.

Mateusz MakuchRobert WilsonAdam Al-DiwaniJames VarleyAnne-Kathrin KienzlerJennifer TaylorAntonio BerrettaDarren FowlerBelinda R LennoxM Isabel LeitePatrick WatersSarosh R Irani

Published in: Annals of neurology (2019)

Serum NR1-IgM and NR1-IgG, alongside the consistent production of NR1-IgG from circulating B cells and from ovarian teratomas suggest that ongoing germinal center reactions may account for the peripheral cell populations which secrete NR1-IgG. Cells participating in germinal center reactions might be a therapeutic target for the treatment of NMDAR-antibody encephalitis. Ann Neurol 2018;83:553-561.

Keyphrases

induced apoptosis
single cell
cell cycle arrest
cell therapy
stem cells
cell death
signaling pathway
bone marrow
endoplasmic reticulum stress
combination therapy
neural network