Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas.

Kristyn GalbraithMekka GarciaSiyu WeiAnna ChenChanel SchroffJonathan SerranoDonato PacioneDimitris G PlacantonakisChristopher M WilliamArline FaustinDavid ZagzagMarissa BarbaroMaria Del Pilar Guillermo Prieto EiblMitsuaki Shirahata David ReussQuynh T TranZahangir AlomAndreas von Deimling Brent A OrrErik P SulmanJohn G GolfinosDaniel A OrringerRajan JainEvan LiebermanYang FengMatija Snuderl

Published in: Neuro-oncology (2024)

The current WHO recognized grading criteria for IDH mutant astrocytomas show limited prognostic value. Stratification based on DNA methylation shows superior prognostic value for OS.

Keyphrases

dna methylation
wild type
genome wide
gene expression
low grade
copy number