Sound Exposure Promotes Intratympanic Drug Delivery to the Inner Ear.

Omer Jacob UngarYumai SituJennifer L SpiegelJoseph M ChenVincent Y W LinTrung N Le

Published in: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2024)

Low-intensity noise (30 dB SPL) was found to enhance dexamethasone phosphate and gentamicin diffusion to the inner ear (by an averaged factor of ∼1.4 and 1.7, respectively) in a murine model.

Keyphrases

drug delivery
low dose
air pollution
high dose
cancer therapy