Plasmonic Resonance Energy Transfer Enhanced Photodynamic Therapy with Au@SiO2@Cu2O/Perfluorohexane Nanocomposites.
Conghui LiuHaifeng DongNianqiang WuYu CaoXue-Ji ZhangPublished in: ACS applied materials & interfaces (2018)
Reactive oxygen species generation efficiency of photosensitizers and hypoxia microenvironment in solid tumor hamper photodynamic therapy (PDT) efficacy. Here, we introduce an efficient inorganic photosensitizer by incorporating plasmonic gold metal nanostructures into Cu2O semiconductors for PDT. By utilizing the plasmon-induced resonance energy transfer (PIRET) process from Au to Cu2O, Au@SiO2@Cu2O (ASC) demonstrates a high singlet oxygen quantum yield of 0.71 under a 670 nm laser irradiation. The ASC is loaded into oxygen self-enriched perfluorohexane (PFH) droplets and coated with liposome (Lip) to form Lip(ASC/PFH) nanocomposites. The achieved Lip(ASC/PFH) shows considerable anticancer efficacy for in vitro cancer cells and in vivo tumor growth. The proposed oxygen self-enriched PIRET-PDT concept has significant implication in PDT design.
Keyphrases
- energy transfer
- photodynamic therapy
- reduced graphene oxide
- quantum dots
- sensitive detection
- nlrp inflammasome
- fluorescence imaging
- reactive oxygen species
- aqueous solution
- visible light
- metal organic framework
- gold nanoparticles
- drug delivery
- stem cells
- high glucose
- endothelial cells
- carbon nanotubes
- cancer therapy
- radiation therapy
- magnetic nanoparticles
- drug induced
- single molecule
- wound healing