Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.
Shaobo YaoKongzhen HuGang-Hua TangSiyuan GaoCaihua TangBaoguo YaoDahong NieTing SunShende JiangPublished in: BioMed research international (2015)
In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.
Keyphrases
- pet imaging
- induced apoptosis
- endoplasmic reticulum stress
- cell death
- oxidative stress
- positron emission tomography
- high throughput
- signaling pathway
- cell cycle arrest
- anti inflammatory
- single cell
- high resolution
- low dose
- single molecule
- quantum dots
- type diabetes
- high fat diet induced
- escherichia coli
- klebsiella pneumoniae
- squamous cell carcinoma
- mesenchymal stem cells
- photodynamic therapy
- transcription factor
- metabolic syndrome
- wild type