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A Novel Imidazopyridine Derivative Exhibits Anticancer Activity in Breast Cancer by Inhibiting Wnt/β‑catenin Signaling.

Liu-Jun HeDong-Lin YangHe-Ying ChenJiu-Hong HuangYa-Jun ZhangHong-Xia QinJuan-Li WangDian-Yong TangZhong-Zhu Chen
Published in: OncoTargets and therapy (2020)
C188 treatment resulted in the downregulation of cyclin D which led to cell cycle arrest at the G1 phase, and the inhibition of cell migration, indicating that C188 may be an effective novel therapeutic candidate as a potential treatment for human breast cancer.
Keyphrases
  • cell cycle arrest
  • cell migration
  • signaling pathway
  • cell death
  • endothelial cells
  • stem cells
  • pi k akt
  • cell cycle
  • induced pluripotent stem cells