Ca2+/nuclear factor of activated T cells signaling is enriched in early-onset rectal tumors devoid of canonical Wnt activation.
Raju KumarRatheesh RamanViswakalyan KotapalliSwarnalata GowrishankarSaumyadipta PyneJonathan R PollackMurali Dharan BashyamPublished in: Journal of molecular medicine (Berlin, Germany) (2017)
Early-onset sporadic rectal cancer exhibits DNA gain and loss without Wnt activation. Ca2+/NFAT signaling appears to be activated in the absence of Wnt activation. An eight-gene genetic signature distinguishes Wnt+ and Wnt- rectal tumors. NFAT and its target genes regulate tumorigenic properties in CRC cells.
Keyphrases
- early onset
- nuclear factor
- late onset
- cell proliferation
- rectal cancer
- stem cells
- genome wide
- toll like receptor
- induced apoptosis
- locally advanced
- copy number
- oxidative stress
- squamous cell carcinoma
- cell death
- endoplasmic reticulum stress
- cell free
- gene expression
- single molecule
- genome wide analysis
- amyotrophic lateral sclerosis
- circulating tumor cells