Identification and characterization of novel CD274 (PD-L1) regulating microRNAs and their functional relevance in melanoma.

Christoforos K VaxevanisMichael FriedrichSandy Uta TretbarDiana HandkeYuan WangJuliane BlümkeReinhard DummerChiara MassaBarbara Seliger

Published in: Clinical and translational medicine (2022)

These data revealed a novel mechanism that miRNAs targeting the CDS of immune checkpoint genes are functional, have prognostic relevance, and also the potential for the development of novel miRNA-based therapies.

Keyphrases

quantum dots
electronic health record
single cell
big data
cancer therapy
gene expression
climate change
artificial intelligence
data analysis
bioinformatics analysis