The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer.
Katie A ThiesMatthew W ColeRachel E SchaferJonathan M SpeharDillon S RichardsonSarah A SteckManjusri DasArthur W LianAlo RayReena ShakyaSue E KnoblaughCynthia D TimmersMichael C OstrowskiArnab ChakravartiGina M SizemoreSteven T SizemorePublished in: Breast cancer research : BCR (2021)
Together, these data demonstrate important but paradoxical roles for RALA and RALB in the pathogenesis of TNBC and advocate further investigation of RALA as a target for the precise treatment of metastatic TNBC.