Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.
Benjamin BayerAndreas MaccaniJohanna JahnMark DuerkopEwald KapellerRobert PletzenauerBarbara KrausGerald StriednerJuan A Hernandez BortPublished in: Biotechnology letters (2021)
The potential of PTR-MS for HEK 293 cell culture monitoring has been shown. VOC data derived information can be used to develop soft sensors and to directly set up new process control strategies.
Keyphrases
- mass spectrometry
- gene therapy
- liquid chromatography
- multiple sclerosis
- ms ms
- health information
- gas chromatography
- high performance liquid chromatography
- capillary electrophoresis
- electron transfer
- single cell
- social media
- high resolution
- electronic health record
- cell therapy
- big data
- blood glucose
- stem cells
- tandem mass spectrometry
- risk assessment
- mesenchymal stem cells
- weight loss
- artificial intelligence