Tomatidine and analog FC04-100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp.
Isabelle GuaySimon BoulangerCharles IsabelleEric BrouilletteFélix ChagnonKamal BouarabEric MarsaultFrançois MalouinPublished in: BMC pharmacology & toxicology (2018)
Chemical modifications of TO allowed improvement of its antibacterial activity against prototypical S. aureus and of its bactericidal activity against L. monocytogenes. Antibacterial activities against such prominent pathogens could be useful to prevent Listeria contamination in the food chain or as treatment for MRSA infections.
Keyphrases
- staphylococcus aureus
- silver nanoparticles
- listeria monocytogenes
- methicillin resistant staphylococcus aureus
- human health
- risk assessment
- drinking water
- biofilm formation
- health risk
- gram negative
- pseudomonas aeruginosa
- antimicrobial resistance
- climate change
- combination therapy
- multidrug resistant
- cystic fibrosis
- wound healing