Evaluation of enteral and parenteral hyaluronic acid in induced ischemic skin flaps in rats: a double-blinded and randomized study.
Marina Frazatti GallinaIvan Felismino Charas Dos SantosBruna Martins da SilvaGuilherme Cirino Coelho PereiraLucas Fernando Sérgio GushikenCláudia Helena PellizzonMiriam Harumi TsunemiSandro de Vargas SchonsFernando do Carmo SilvaKamile Daguano SenaVinicius Dos Santos RosaPublished in: Acta cirurgica brasileira (2024)
High molecular HA (1,400 ~ 2,000 kDa) administrated by subcutaneous or oral route exhibited beneficial effects in ischemic skin flaps of rats. However, subcutaneous administration of HA (0.3%) showed better results in terms of the percentage of necrosis and epithelialization.