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Palbociclib and Trastuzumab in HER2-Positive Advanced Breast Cancer: Results from the Phase II SOLTI-1303 PATRICIA Trial.

Eva Ciruelos GilPatricia VillagrasaTomás PascualMafalda OliveiraSonia PernasLaia ParéSantiago Escriva-de-RomaniLuis Manso SanchezBarbara AdamoE Martínez de DueñasJavier CortesSilvia VazquezAntonia PerellóIsabel GarauMireia MeléAlvaro MontañoBegoña BermejoSerafin Morales MurilloMaría J EcharriEstela VegaBlanca Gonzalez-FarrePatricia GalvánJordi CanesPaolo G NuciforoXavier GonzalezAleix Prat
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Palbociclib in combination with trastuzumab is safe and exhibits promising survival outcomes in trastuzumab pretreated ER-positive/HER2-positive advanced breast cancer with a PAM50 Luminal A or B subtype. The enrollment was stopped prematurely, and a new randomized cohort was opened in this population.
Keyphrases
  • phase ii
  • metastatic breast cancer
  • clinical trial
  • open label
  • phase iii
  • epidermal growth factor receptor
  • double blind
  • placebo controlled
  • health insurance
  • young adults
  • affordable care act