Reduced dopamine transporter availability in drug-naive adult attention-deficit/hyperactivity disorder.

Shuntaro ItagakiTakashi OhnishiWataru TodaAya SatoJunya MatsumotoHiroshi ItoShiro IshiiRyo YamakuniItaru MiuraHirooki Yabe

Published in: PCN reports : psychiatry and clinical neurosciences (2024)

In drug-naive adult patients with ADHD, DAT availability was reduced in the nucleus accumbens, an important part of the reward system. This finding indicates the importance of the DAT in the reward system in the pathogenesis of ADHD. Inattentiveness was associated with DAT availability in the caudate nucleus, suggesting involvement of the cortico-striato-thalamo-cortical circuit.

Keyphrases

attention deficit hyperactivity disorder
autism spectrum disorder
working memory
hiv infected
prefrontal cortex
adverse drug
uric acid
drug induced
metabolic syndrome
childhood cancer