Determinants of selection in yeast evolved by genome shuffling.
Damien Biot-PelletierDominic PinelKane LarueVincent J J MartinPublished in: Biotechnology for biofuels (2018)
We use these data to propose a model of inhibitor tolerance in our GS mutants. Our results also suggest a role for compensatory evolution and epistasis in our genome shuffling experiment and illustrate the impact of historical contingency on the outcomes of evolutionary engineering.