Association between insulin growth factor-1, bone mineral density, and frailty phenotype in children with chronic kidney disease.

Vasiliki KaravaJohn DotisAthanasios ChristoforidisVassilios LiakopoulosAntonia KondouGeorgios TsigarasKonstantina TsioniKonstantinos KolliosNikoleta Printza

Published in: Pediatric nephrology (Berlin, Germany) (2021)

Frailty phenotype is more frequent in advanced pediatric CKD. IGF-1 is negatively associated with frailty phenotype and interferes in the association between frailty and LBMAD.

Keyphrases

growth factor
bone mineral density
chronic kidney disease
community dwelling
postmenopausal women
end stage renal disease
body composition
type diabetes
young adults
cell proliferation
pi k akt
insulin resistance