Cinchona alkaloids - acid, anion-driven fluorescent INHIBIT logic gates with a receptor 1 -fluorophore-spacer-receptor 2 format and PET and ICT mechanisms.

The fluorescent natural products, quinine, quinidine, cinchonine and cinchonidine are demonstrated as H + -enabled, halide-disabled (Cl - , Br - or I - ) INHIBIT and INHIBIT-OR combinatorial logic gates in water. More fluorescent natural products with intrinsic logic properties await to be discovered.