Risk of osteoporosis in testicular germ cell tumour survivors: A systematic review of the literature.
Josephina P M VrouwePauline M L HennusNeveen A T HamdySusanne OsantoPeter-Paul M WillemsePublished in: BJUI compass (2022)
TGCT survivors are at risk of developing osteoporosis and sustaining fragility fractures. Chemotherapy, pituitary-gonadal axis dysfunction and ageing are key risk factors, although available data are scarce. With increasing survival of TGCT patients, a clear unmet need has been identified to systematically evaluate and monitor skeletal health in larger numbers of survivors in order to develop best clinical practice guidelines to manage the insidious but potentially preventable and treatable skeletal complications of TGCT.
Keyphrases
- germ cell
- risk factors
- young adults
- postmenopausal women
- end stage renal disease
- bone mineral density
- ejection fraction
- newly diagnosed
- healthcare
- public health
- chronic kidney disease
- mental health
- prognostic factors
- oxidative stress
- squamous cell carcinoma
- radiation therapy
- big data
- free survival
- deep learning
- human health
- artificial intelligence
- rectal cancer