Contributions of cholinergic receptor muscarinic 1 and CYP1A2 gene variants on the effects of plasma ratio of clozapine/N-desmethylclozapine on working memory in schizophrenia.

Farhana IslamMalgorzata MaciukiewiczNatalie FreemanEric HuangArun TiwariBenoit H MulsantBruce G PollockGary RemingtonJames L KennedyDaniel J MuellerTarek K Rajji

Published in: Journal of psychopharmacology (Oxford, England) (2020)

Our finding that the relationship between clozapine/N-desmethylclozapine and working memory is specific to patients with potentially higher transcription of M1 receptor (i.e. non-carriers of the haplotype T-A of cholinergic receptor muscarinic 1) supports a cholinergic mechanism underlying this relationship.

Keyphrases

working memory
transcranial direct current stimulation
attention deficit hyperactivity disorder
copy number
bipolar disorder
genome wide
binding protein
dna methylation