circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling.

Lin ZhengHui LiangQiaoling ZhangZichu ShenYixin SunXuyang ZhaoJingjing GongZhiyuan HouKewei JiangQuan WangYan JinYuxin Yin

Published in: Molecular cancer (2022)

Our study uncovered a novel PTEN gene-generated circRNA with a tumor suppression function, and further revealed the mechanism of circPTEN1 in CRC metastasis mediated by TGF-β. The identification of circPTEN1 provides a new direction for PTEN investigation, and elucidation of circPTEN1/TGF-β/Smad signaling may pave the way for the development of a potential therapeutic strategy for the suppression of cancer progression.

Keyphrases

transforming growth factor
papillary thyroid
epithelial mesenchymal transition
cell proliferation
pi k akt
squamous cell
signaling pathway
lymph node metastasis
copy number
squamous cell carcinoma
young adults
transcription factor