Exosomes derived from human CD34+ stem cells transfected with miR-26a prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis.

Rongtai ZuoLingchi KongMengwei WangWenbo WangJia XuYimin ChaiJunjie GuanQinglin Kang

Published in: Stem cell research & therapy (2019)

MiR-26a-CD34+-Exos protect the femoral head from damage caused by GCs by strengthening angiogenesis and osteogenesis. The biological effect of miR-26a-CD34+-Exos make them suitable for application in the prevention of GC-induced ONFH.

Keyphrases

endothelial cells
high glucose
cell proliferation
stem cells
long non coding rna
long noncoding rna
diabetic rats
vascular endothelial growth factor
oxidative stress
drug induced
wound healing
high resolution
mass spectrometry
cell therapy