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Population Pharmacokinetic-Pharmacodynamic Modeling of Carvedilol to Evaluate the Effect of Cytochrome P450 2D6 Genotype on the Heart Rate Reduction.

Sejung HwangSoyoung LeeJangsoo YoonJae-Young Chung
Published in: Journal of Korean medical science (2023)
genetic polymorphisms were contributed to the inter-individual variability of carvedilol PK, but not PD.
Keyphrases
  • heart rate
  • heart rate variability
  • blood pressure