Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice.

Xian WuPer M UelandJatin RoperGar Yee KohXu LiangJimmy W CrottÖmer H YilmazRoderick T BronsonJoel B Mason

Published in: The Journal of nutrition (2022)

In this mouse model, C + B is superior to either agent alone in preventing obesity-promoted colorectal carcinogenesis. Augmented suppression of procancerous signaling pathways may be the means by which this augmentation occurs.

Keyphrases

high fat diet induced
insulin resistance
mouse model
signaling pathway
metabolic syndrome
weight loss
type diabetes
weight gain
skeletal muscle
adipose tissue
epithelial mesenchymal transition
pi k akt
soft tissue
cell proliferation
oxidative stress