Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time.
Pratik SinhaLucile P A NeytonAartik SarmaNelson WuChayse JonesHanjing ZhuoKathleen D LiuEstella Sanchez GuerreroRajani GhaleChristina LoveEran MickKevin L DelucchiCharles R LangelierB Taylor ThompsonMichael A MatthayCarolyn S Calfeenull nullPublished in: American journal of respiratory and critical care medicine (2024)
The Hyperinflammatory and Hypoinflammatory phenotypes have different clinical, protein, and dynamic transcriptional characteristics. These findings support the clinical and biological potential of molecular phenotypes to advance precision care in ARDS.
Keyphrases
- gene expression
- acute respiratory distress syndrome
- healthcare
- extracorporeal membrane oxygenation
- dna methylation
- mechanical ventilation
- clinical trial
- palliative care
- transcription factor
- single molecule
- phase iii
- small molecule
- protein protein
- pain management
- oxidative stress
- open label
- binding protein
- glycemic control
- affordable care act
- double blind